Finanzierte Projekte

Year	Title	Duration	Lab
2023	Unstructured proteins as therapeutic targets for neuromuscular diseases	2	Dr. Leonidas Emmanouilidis, ETH Zürich
2023	Open and reproducible pipeline for the acquisition and analysis of muscle MRI data in Facioscapulohumeral Muscular Dystrophy	1	Dr. Claudia Weidensteiner, University Hospital Basel
2023	Dissecting lysosomal signals to fight Pompe disease	1	Dr. Andrea Armani, University of Zürich
2023	Functional properties and epigenetic signature of quiescent and early activated human muscle reserve cells	3	Dr. Thomas Laumonier, University of Geneva
2022	Activation of human skeletal muscle stem cells:role of Orai3 and its partner AHNAK2 in physiological condition and in Duchenne muscular dystrophy	3	Prof. Maud Frieden, University of Geneva
2022	Understanding the clinical spectrum associated with VMA21 deficiency	3	Prof. Perrine Castets, University of Geneva
2022	ANTXR2 as a key player in Collagen VI signaling in muscle stem cells: New therapeutic perspectives for COL6-related myopathies	2	Prof. Gisou van der Goot, EPFL Lausanne
2022	Molecular mechanisms of complement activation and neuromuscular disruption by combinations of autoantibodies from patients with Myasthenia Gravis	3	Dr. Nicholas Sanderson, University Hospital Basel
2021	From the investigation of the role of SRSF1 in ALS/FTD to its targeting as a therapeutic strategy	3	Prof. Frédéric Allain, ETH Zürich
2021	Molecular crosstalk between muscles and motor neurons and its role in neuromuscular circuit formation	2	Prof. Patrick Tschopp, University of Basel
2021	Molecular Diagnosis and Coping Mechanisms in Mitochondrial Myopathies	3	Prof. Alexis Jourdain, University of Lausanne
2021	IPRIMYO: Immune-privileged, immortal, myogenic stem cells for gene therapy of Muscular Dystrophy (Paul Pettavino Fellowship)	2	Dr. Marisa Jaconi, University of Geneva
2021	Effect of RYR1 mutations on muscle spindle function and their impact on the musculoskeletal system	2	Profs. Susan Treves and Francesco Zorzato, University Hospital Basel
2021	Therapeutic potential of human myogenic reserve cells in Duchenne Muscular Dystrophy	1	Dr. Thomas Laumonier, University of Geneva
2021	Glutamine metabolism as a potential target for Duchenne Muscular Dystrophy	1	Dr. Inés Soro-Arnàiz, ETH Zürich
2021	Targeting protein s-acylation during Tubular Aggregate Myopathy	2	Dr. Amado Carreras, University of Geneva
2021	Aggravating the phenotype of dystrophic mice for improving preclinical research and clinical translation for Duchenne muscular dystrophy	1	Dr. Olivier Dorchies, University of Geneva
2020	Characterization of autoreactive T cells in Guillain-Barré syndrome (Paul Pettavino Fellowship)	3	Dr. Daniela Latorre, ETHZ, Zürich
2020	A vascularized human muscle-on-a-chip to elucidate the contribution of endothelial-mesenchymal transition on the progression of muscular dystrophies	3	Dr. Simone Bersini, Ente Ospedaliero Cantonale, Lugano
2020	Characterization of a novel form of ALS associated with changes in the sphingolipid metabolism	3	Dr. Museer Lone, University of Zürich
2020	Pre-clinical treatment of mouse models carrying recessive Ryr1 mutations with HDAC/DNA methyltransferase inhibitors.	1	Profs. Susan Treves and Francesco Zorzato, Basel University Hospital
2020	New aspects of TGFβ signaling in muscle homeostasis and regeneration	3	Dr. Michael Bachmann University of Geneva
2020	Inhibition of sphingolipid synthesis as a treatment strategy for Duchenne muscular dystrophy	2	Prof. Johan Auwerx, EPFL, Lausanne
2019	Tamoxifen in Duchenne muscular dystrophy (TAMDMD)	2	Dr. med. Dirk Fischer, UKBB Basel
2019	DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD	2	Dr. Jochen Kinter and Dr. Christian Klingler, University of Basel
2019	Facilitating diagnosis of critical illness myopathy using muscle excitability testing	2	Prof. med. Werner J. Z'Graggen, Inselspital Bern
2019	Rapid Exploratory Imaging for High-resolution and Whole Extremity Coverage in MR Neurography	2	Dr. Olivier Scheidegger, Inselspital Bern
2019	Deciphering novel mechanisms and effectors contributing to muscle dysfunction in Myotonic Dystrophy Type I	1	Prof. Perrine Castets, University of Geneva
2018	Can HDAC/DNA methyltransferase inhibitors improve muscle function in a congenital myopathy caused by recessive RYR1 mutations?	2	Prof. Francesco Zorzato and Prof. Susan Treves, University Hospital Basel
2018	Identification of the critical regulators of protein synthesis and degradation in human muscle atrophy	2	Dr. Lionel Tintignac and Dr. Nitish Mittal, University of Basel
2018	Exploring peripheral B-cell-helper T cell phenotypes in the blood of patients with Myasthenia gravis using mass cytometry (CyTOF)	1	Dr. med. Bettina Schreiner, University Hospital Zürich
2018	Molecular signature, metabolic profile and therapeutic potential of human myogenic reserve cells	3	Dr. Thomas Laumonier, University of Geneva
2018	A multicenter cross-sectional and longitudinal study of the Swiss cohort of Merosin-negative congenital muscular dystrophy	3	Dr. med. Andrea Klein, UKBB Basel
2018	Targeting NADPH oxidase 4 in models of Duchenne muscular dystrophy (extension of project 2016)	1	Dr. Hesham Hamed, University of Geneva
2017	Characterizing the role of ER stress in C9orf72-linked ALS pathology	2	Prof. Smita Saxena, Inselspital, University of Bern
2017	Inducing mitophagy with Urolithin A to restore mitochondrial and muscle function in muscular dystrophy	2	Prof. Johan Auwerx, EPFL Lausanne
2017	Exercise‐based interventions in dysferlinopathies	2	Prof. Christoph Handschin, Biozentrum Basel
2017	Motor unit action potentials analysis in patients with myopathies with a new wireless portable and multichannel Surface EMG device (WPM-SEMG)	2	Prof. Alain Kälin, Neurocentro della Svizzera Italiana, Lugano
2017	Role and therapeutic potential of PLIN3 in neuromuscular diseases	2	Dr. Francesca Amati, University of Lausanne
2017	Changes in ventilation distribution in children with neuromuscular disease using the insufflator/exsufflator technique: An observational study	1	Dr. med. Thomas Riedel, Kantonsspital Graubünden, Chur
2016	Mechanism and function of genome organization in muscle development and integrity	2	Prof. Susan Gasser, Friederich Miescher Institute, Basel
2016	Role and therapeutic potential of NADPH oxidases in a mouse model of Duchenne Muscular Dystrophy	2	Dr. Hesham Hamed, University of Geneva
2016	Characterization of pathological pathways activated in muscles of patients with congenital myopathies with disturbed Ca2+ homeostasis	2	Prof. Susan Treves, Basel University Hospital
2016	Creation of a study team to conduct an SMA-1 clinical trial at the Centre for Neuromuscular Diseases at the University Children's Hospital Basel (UKBB)	1	Dr. med. Andrea Klein, Universitäts-Kinderspital beider Basel (UKBB)
2015	Novel treatment to stop progressive neuropathy and muscle weakness in multifocal motor neuropathy	3	Dr. Ruben Herrendorff, University of Basel
2015	Understanding the pathomechanisms leading to muscle alterations in Myotonic Dystrophy type I	3	Dr. Perrine Castets, University of Basel
2015	Automated volumetry and quantitative MRI to diagnose peripheral nerve lesions – translational proposal for a new clinical diagnostic imaging tool	2	Dr. Olivier Scheidegger, Inselspital Bern
2015	Novel approaches against Spinal Muscular Atrophy by targeting splicing regulators	2	Prof. Frédéric Allain, ETH Zürich
2015	Protective effects and mechanisms of action of tamoxifen in mice with severe muscular diseases	3	Dr. Olivier Dorchies, University of Geneva
2015	Role of the receptor FgfrL1 in the development of slow muscle fibers	2	Prof. Beat Trueb, University of Bern
2015	Muscle velocity recovery cycles: A new tool for early diagnosis of critical illness myopathy	1	Prof. med. Werner J. Z'Graggen, Inselpital Bern
2014	Generation of uncomitted human IPSC derived muscle stem cells for therapeutic applications	3	Dr. Florian Bentzinger, Nestlé Institute of Health Sciences, Lausanne
2014	Transposable vectors for dystrophin-expression in a murine model for muscular dystrophy	3	Prof. Nicolas Mermod, University of Lausanne
2014	Cardiac involvement in patients with Duchenne/Becker Muscular Dystrophy; an observational study	1	Dr. med. Andrea Klein, Children University Hospital Zürich
2014	Deciphering the pathogenic mechanisms of C9ORF72 ALS co-funded by ASLASI (Associazione Sclerosi Laterale Amiotrofica Svizzera Italiana)	3	Dr. Magdalini Polymenidou, University of Zürich
2014	Development of magnetic resonance methods for functional imaging of the skeletal muscle	2	Dr. Francesco Santini, Basel University Hospital
2013	Enhancing estrogenic signalling to fight muscular dystrophies: Mechanisms of action and repurposing clinically approved drugs	2	Dr. Olivier Dorchies, University of Geneva
2013	Mechanisms and therapeutic potential of modulating PGC‐1α to alter neuromuscular junction morphology and function	2	Prof. Christoph Handschin, University of Basel
2013	Triggering human myoblast differentiation: from EGFR to myogenic transcription factors	3	Prof. Laurent Bernheim, University of Geneva
2013	Improving cellular therapies of muscle dystrophies by uncovering epigenetic and signaling pathways of muscle formation co-funded by Schweizerische Muskelgesellschaft	3	Prof. Peter Meister, University of Bern
2013	Protein engineering in an attempt to increase the mechanical, integrin dependent cytoskeleton-matrix linkage in muscle fibers	1	Prof. Bernhard Wehrle-Haller, University of Geneva
2012	Evaluation of novel treatment strategies for dysferlinopathies in mouse models	1	Prof. med. Michael Sinnreich, University Hospital Basel
2012	Cell therapy of LGMD2D by donor HLA-characterized human mesoangioblasts (hMABs) produced in GMP conditions	3	Dr. Marisa Jaconi, University of Geneva
2012	In search of small molecules targeting protein-RNA complex: a novel approach against Spinal Muscular Atrophy	3	Prof. Frédéric Allain, ETH Zürich
2012	Targeting ER stress response: a potential mechanism for neuroprotection in Amyotrophic Lateral Sclerosis co-funded by ASLASI (Associazione Sclerosi Laterale Amiotrofica Svizzera Italiana)	1	Prof. Smita Saxena, University of Bern
2012	Restoration of autophagy as a new strategy for the treatment of congenital muscular dystrophies	3	Prof. Markus A. Rüegg, University of Basel
2011	SRP-35, a newly identified skeletal muscle protein linking excitation-contraction coupling to activation of metabolism	1	Prof. Susan Treves, University of Basel
2011	Muscle veocity recovery cycles: a new tool for characterization of muscle disease in vivo co-funded by Schweizerische Muskelgesellschaft	1.5	Prof. med. Werner J. Z'Graggen, Inselspital Bern
2011	Excessive neurotrypsin activation and agrin cleavage-a pathogenic condition leading to sarcopenia-like muscle atrophy?	1	Prof. Peter Sonderegger, University of Zürich

Von 1987 bis 2010 hat die Stiftung 107 weitere Forschungsprojekte finanziert.

Finanzierte Projekte

Year

Title

Duration

Lab

Projekte

FSRMM